VA Maryland Health Care System
Maryland VA Health Care System Participates in the MVP
The Department of Veterans Affairs (VA) Million Veteran Program (MVP) recently enrolled its 100,000th volunteer research participant, and now stands at more than 133,000 enrollees, marking a major milestone in the nearly 90-year history of VA research. The Maryland VA Health Care System, which is participating in the effort to make medical history, has enrolled more than 1,700 Veterans in the program and expects to enroll 20,000 total in the next five to seven years. The health care system recently opened a second enrollment site at its Glen Burnie VA Outpatient Clinic to increase Veterans’ options to enroll in the research program.
“MVP is a truly historic effort, in terms of both VA research and medical research in general,” said Secretary of Veterans Affairs Eric K. Shinseki. “Veterans nationwide are helping to create a database that has the potential to help millions around the country – Veteran and non-Veteran alike. They are continuing to serve the nation well beyond the time they stopped wearing the uniform.”
Launched in 2011, MVP is a landmark research effort aimed at better understanding of how genes affect health. Up to a million Veterans are expected to enroll in the VA study over the next six years. Data and genetic samples collected through the study are stored securely and made available for studies by authorized researchers, with stringent safeguards in place to protect Veterans’ private health information. MVP is now at 43 VA medical centers nationwide, with additional VA sites opening for enrollment in the coming year.
With more than 133,000 enrollees to date, MVP already far exceeds the enrollment numbers of any single VA study or research program in the past.
“This milestone has come about thanks to our Veteran participants and lots of hard work and dedication on the part of VA researchers and the entire MVP team,” said VA Under Secretary for Health Dr. Robert Petzel.
VA Chief Research and Development Officer Dr. Joel Kupersmith added, “VA could not have achieved this without our altruistic Veteran volunteers.” He called MVP “an extremely important partnership that is paving the road toward the world’s largest database of health information and improved health care for future generations.”
MVP provides researchers with a rich resource of genetic, health, lifestyle, and military-exposure data collected from questionnaires, medical records, and genetic analyses. By combining this information into a single database, MVP promises to advance knowledge about the complex links between genes and health. Authorized researchers are able to use MVP data to help answer important questions on a wide range of health conditions affecting Veterans, from military-related conditions such as post-traumatic stress disorder and traumatic brain injury, to common chronic illnesses such as diabetes and heart disease.
“Imagine a database comprised of genetic material of 1 million people. Imagine being able to know why a certain medicine can help one person, while making another sick. Imagine learning why ten people experience mild allergic reactions, while another group experiences severe allergic reactions, and still another group remains unaffected to the same trigger. Imagine your doc using your own genetic information to determine the best way to treat your ailments and disease states. It's called Personalized Medicine and it's here,” says Dr. Alan Shuldiner, MD, a physician and researcher at the VA Maryland Health Care System and associate dean for Personalized & Genomic Medicine and head of the Division of Endocrinology, Diabetes & Nutrition at University of Maryland School of Medicine. Shuldiner, who is best known for his Amish Family Osteoporosis Study, is the principle investigator for the Maryland segment of the MVP research program.
MVP-related discoveries also promise to advance the field of personalized medicine, which aims to tailor medical care based on people’s individual genetic profiles. Personalized medicine is expected to yield more effective treatments and reduce costs, given its emphasis on prevention.
Veterans’ privacy and confidentiality are top priorities in MVP, as in all VA research. Rigorous measures are taken to protect MVP participants’ personal information, including secure storage of data and samples using a bar-code system. Researchers approved for access to MVP data do not receive the name, date of birth, social security number, or address of participating Veterans. Furthermore, authorized researchers conduct their analyses only within VA’s secure, centralized computing environment, known as GenISIS (Genomic Information System for Integrated Science).
Veterans interested in joining the more than 1,700 VA Maryland Health Care System participants, may visit the MVP team at the Baltimore VA Medical Center, located at 10 N. Greene St., Baltimore, Md., in room 4B-210. Walk-in hours are Mondays to Thursdays from 8 a.m. to 4 p.m., and Fridays from 8 a.m. to Noon. Veterans may also join the MVP program at the Glen Burnie VA Outpatient Clinic, located at 808 Landmark Drive Suite 128, Glen Burnie, Md. Appointments are available at 1-866-441-6075.
For more information about MVP, visit www.research.va.gov/MVP